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BIOSIS Previews covers the entire field of life sciences,
including their classification, life processes, environments and
applications. It presents published research findings and
literature references from the biological sciences and
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and theoretical work.
The database covers the basic biological disciplines of
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related interdisciplinary fields including biochemistry,
bioengineering, agriculture, ecology, food science,
research medicine, biotechnology, environmental studies and
pharmacology.
Use BIOSIS to find:
- a paper published in The Lancet on alcoholic intake in
pregnancy
- data on viral diseases of spinach
- recent data on microtubules of flagellate protozoa
Within BIOSIS the types of data available may be restricted to
certain years. Details of any year restrictions are given for
individual data paragraphs.
Sources:
Over 5000 journals as well as monographs, reports, reviews, books,
meeting literature and research communications from all over the
world are indexed. For more recent years, U.S. patents are also
included. Abstracts are added for approximately 80% of the journal
literature and for book synopses. The geographic coverage of
BIOSIS Previews is: Europe and the Middle East 51%, North America
31%, Asia and Australasia 14%, Central and South America 3%,
Africa 1%.
Journal article
AN - Accession number & update
PREV200800361800 20080626.
AU - Author(s)
Majewski-Ian-J, Blewitt-Marnie-E, de-Graaf-Carolyn-A, McManus-
Edward-J, Bahlo-Melanie, Hilton-Adrienne-A, Hyland-Craig-D,
Smyth-Gordon-K, Corbin-Jason-E, Metcalf-Donald, Alexander-
Warren-S, Hilton-Douglas-J Email: hilton@wehi.edu.au.
TI - Title
Polycomb repressive complex 2 (PRC2) restricts hematopoietic
stem cell activity.
SO - Source
PLoS Biology, APR 2008, vol. 6, no. 4, p. 796-809,
DOI: doi:10.1371/journal.pbio.0060093,
eISSN: 1545-7885, ISSN: 1544-9173.
IN - Author affiliation
Hilton-Douglas-J, Royal Melbourne Hosp, Walter and Eliza Hall
Inst Med Res, Parkville, Vic 3050, Australia.
LG - Language
English.
YR - Publication year
2008.
PT - Publication type
Article.
DE - Descriptors
Major Concepts:
Molecular-Genetics (Biochemistry-and-Molecular-Biophysics);
Blood-and-Lymphatics (Transport-and-Circulation).
Organisms:
Biosystematic Code: Muridae (86375): Super Taxa: Rodentia#,
Mammalia#, Vertebrata#, Chordata#, Animalia#, Taxa Notes:
Animals#, Chordates#, Mammals#, Nonhuman-Vertebrates#,
Nonhuman-Mammals#, Rodents#, Vertebrates#;
mouse: strain-C57BL-6.
Parts Structures & Systems of Organisms:
platelet: blood-and-lymphatics;
hematopoietic-stem-cell: blood-and-lymphatics;
chromosome-11.
Diseases:
thrombocytopenia: Thrombocytopenia (MeSH), blood-and-
lymphatic-disease.
Chemicals & Biochemicals:
polycomb-repressive-complex-2 (PRC2);
polycomb-group-proteins: transcriptional-repressor.
Gene Name:
mouse-Suz12-gene-(Muridae) (mouse-suppressor-of-zeste-12-
gene): mutation, expression;
mouse-c-Mpl-gene-(Muridae): expression;
mouse-Plt8-gene-(Muridae): mutation.
Methods & Equipment:
genetic-mapping: laboratory-techniques, genetic-techniques.
Miscellaneous descriptors:
wild-type-genetic-background.
CC - Concept codes
02506 Cytology - Animal;
03502 Genetics - General;
03506 Genetics - Animal;
15002 Blood - Blood and lymph studies;
15004 Blood - Blood cell studies;
15006 Blood - Blood lymphatic and reticuloendothelial
pathologies.
AB - Abstract
Polycomb group proteins are transcriptional repressors that
play a central role in the establishment and maintenance of
gene expression patterns during development. Using mice with
an N-ethyl-N-nitrosourea ( ENU)-induced mutation in Suppressor
of Zeste 12 ( Suz12), a core component of Polycomb Repressive
Complex 2 ( PRC2), we show here that loss of Suz12 function
enhances hematopoietic stem cell ( HSC) activity. In addition
to these effects on a wild-type genetic background, mutations
in Suz12 are sufficient to ameliorate the stem cell defect and
thrombocytopenia present in mice that lack the thrombopoietin
receptor ( c-Mpl). To investigate the molecular targets of the
PRC2 complex in the HSC compartment, we examined changes in
global patterns of gene expression in cells deficient in
Suz12. We identified a distinct set of genes that are
regulated by Suz12 in hematopoietic cells, including eight
genes that appear to be highly responsive to PRC2 function
within this compartment. These data suggest that PRC2 is
required to maintain a specific gene expression pattern in
hematopoiesis that is indispensable to normal stem cell
function.
NT - Notes
Date produced: 20080624.
Meeting poster
AN - Accession number & update
PREV200800350758 20080626.
AU - Author(s)
Assareh-Neda, ElBatsh-Maha-M, Kendall-David-A, Marsden-
Charles-A.
TI - Title
Effect of chronic rimonabant treatment on antidepressant-
related protein expression.
SO - Source
British Journal of Clinical Pharmacology, JUN 2008, vol. 65,
no. 6, p. 991-992,
ISSN: 0306-5251.
CF - Conference information
Meeting of the Clinical Pharmacology Section of the British-
Pharmacological-Society, December 17 -20, 2007 , Brighton, UK,
Sponsor: British Pharmacol Soc, Clinical Pharmacol Sect.
IN - Author affiliation
Assareh-Neda, Univ Nottingham, Sch Biomed Sci, Nottingham NG7
2RD, UK.
LG - Language
English.
YR - Publication year
2008.
PT - Publication type
Meeting (Meeting Poster).
DE - Descriptors
Major Concepts:
Pharmacology; Biochemistry-and-Molecular-Biophysics;
Nervous-System (Neural-Coordination).
Parts Structures & Systems of Organisms:
cerebellum: nervous-system;
hippocampus: nervous-system;
frontal-cortex: nervous-system;
striatum: nervous-system.
Diseases:
obesity: Obesity (MeSH), nutritional-disease;
nicotine-addiction: Substance-Related-Disorders (MeSH),
behavioral-and-mental-disorders, toxicity.
Chemicals & Biochemicals:
brain-derived-neurotrophic-factor (BDNF);
monoamine-oxidase-inhibitors: enzyme-inhibitor-drug;
endocannabinoids;
cannabinoid-CB1-receptor;
cyclic-AMP-response-element-binding-protein (CREB);
tranylcypromine: CAS: 155-09-9, central-depressant-drug,
monoamine-oxidase-inhibitor-drug, anxiolytic-drug,
antidepressant-drug, enzyme-inhibitor-drug, intraperitoneal-
administration, dosage;
Rimonabant: CAS: 168273-06-1, antidepressant-drug,
intraperitoneal-administration, dosage.
Methods & Equipment:
ANOVA: mathematical-and-computer-techniques;
Western-immunoblotting: laboratory-techniques, immunologic-
techniques, genetic-techniques.
Miscellaneous descriptors:
neurotransmitter-release;
freezing-behavior.
CC - Concept codes
00520 General biology - Symposia transactions and proceedings;
07004 Behavioral biology - Human behavior;
10060 Biochemistry studies - General;
10064 Biochemistry studies - Proteins peptides and amino
acids;
12512 Pathology - Therapy;
17020 Endocrine - Neuroendocrinology;
20504 Nervous system - Physiology and biochemistry;
21004 Psychiatry - Addiction: alcohol drugs smoking;
22002 Pharmacology - General;
22024 Pharmacology - Neuropharmacology;
22026 Pharmacology - Psychopharmacology;
22501 Toxicology - General and methods ;
22504 Toxicology - Pharmacology.
NT - Notes
Date produced: 20080624
BIOSIS Update date: 20080611
Reason for update: Correction to source data.
Label/Description Example
AN Accession number 1_: PREV200800361800.AN.
& update 2_: 20080626.AN.
- see also ..LIMIT options -
AU* Author(s) 3_: MAJEWSKI-IAN-J.AU.
A list of similar names 4_: ..ROOT MAJEWSKI-I.AU.
Authors may have initials or
full first names
TI Title (in English) 5_: POLYCOMB ADJ REPRESSIVE.TI.
TT Title in original language 6_: BILAN ADJ HYDRIQUE.TT.
SO Source - Journal name* 7_: PLOS-BIOLOGY.SO.
Journals starting PLOS... 8_: SO=PLOS$
A list of journals starting
WATER... 8_: ..ROOT SO=PLOS
Other Source data e.g. ISSN 9_: ISSN=1544-9173
Source - Book 10_: ENZYME ADJ REGULATION.SO.
Publisher 11_: ELSEVIER.SO.
ISBN 12_: 0-080-44123-8.SO.
CF Conference information 13_: CLINICAL WITH
PHARMACOLOGY.CF.
or 14_: BRIGHTON SAME 2007.CF.
IN Author affiliation 15_: ROYAL WITH MELBOURNE.IN.
LG* Language 16_: LG=ENGLISH
A list of languages 17_: ..ROOT LG=
YR Publication year 18_: YEAR=2008
- see also ..LIMIT options -
PT* Publication type 19_: PT=ARTICLE
20_: PT=MEETING$
A list of publication types 21_: ..ROOT PT=
DE* Descriptors 22_: BLOOD-AND-LYMPHATICS.DE.
or 23_: PLATELET.DE.
or 24_: MOLECULAR ADJ GENETICS.DE.
MC*- Major Concepts 25_: BIOCHEMISTRY.MC.
OR*- Organisms 26_: MOUSE.OR.
- Super Taxa 27_: RODENTIA#
- Taxa Notes 28_: VERTEBRATES#
- Biosystematic Code 29_: 86375.OR.
or 30_: MURIDAE.OR.
PS*- Parts etc. of organism 31_: BLOOD-AND-LYMPHATICS.PS.
DS*- Diseases 32_: THROMBOCYTOPENIA.DS.
CB*- Chemicals & Biochemicals 33_: POLYCOMB-GROUP-PROTEINS.CB.
- CAS Registry 34_: 9068-68-2.CB.
or 35_: RN=9068-68-2
- Enzyme Commission 36_: EC-3-1-6-8.CB.
GN*- Gene name 37_: MOUSE-SUZ12-GENE-MURIDAE.GN.
SD*- Sequence data 38_: NUCLEOTIDE-SEQUENCE.SD.
- Sequence Number 39_: U09103.SD.
- CAS Registry 40_: 157112-35-1.SD.
TM*- Time (Geologic) 41_: UPPER ADJ ALBIAN.TM.
MQ*- Methods & Equipment 42_: GENETIC-MAPPING.MQ.
MI*- Miscellaneous descriptors 43_: WILD-TYPE$.MI.
GA*- Geographic area 44_: NEOTROPICAL.GA.
or 45_: BRITISH ADJ COLUMBIA.GA.
CC* Concept Codes 46_: 02508.CC.
or 47_: CYTOLOGY NEAR ANIMAL.CC.
Broad Codes at 3 digit level 48_: 025#
AB Abstract 49_: TRANSCRIPTIONAL ADJ
REPRESSORS.AB.
PA Patent information
- Number 50_: 6306665.PA.
- Date granted 51_: PD=20011023
or 52_: 20011023.PA.
or for a month 53_: 200110.PA.
- Class 54_: 436-530.PA.
or for a broader search 55_: 436-$.PA.
- Assignee 56_: A ADJ FEM ADJ MEDICAL.PA.
NT Notes 57_: ALTERATION.NT.
- see also ..LIMIT options -
- Date produced 58_: PRODUCED ADJ 20080624.NT.
(*) Phrases in these paragraphs can be searched using hyphens
or the operators ADJ or WITH. The ..ROOT command is useful to
establish what terms are in use.
The following paragraph labels are alternatives, used in the
previous version of BIOSIS:
BC formerly Biosystematic Codes, now a duplicate of OR
KW formerly Keywords, now a duplicate of DE
RN formerly CAS Registry Numbers, now a duplicate of CB
ST formerly Super Taxa, now a duplicate of OR
Note that BC, KW, RN and ST may be removed in a future reload
of BIOSIS, so please use OR, DE, CB, OR instead.
Initial search to select records 1_: LONGEVITY.AB.
UDATE Update date 2_: ..L 1 UDATE>20071231
UMONTH Update month 3_: ..L 1 UMONTH<200801
YEAR Publication year 4_: ..L 1 YEAR WL 2007,2008
ED Entry date 5_: ..L 1 ED>20080129
For a year before 1998 use 6_: ..L 1 ED=19950000.
By paragraph, for example show title and source for the first ten
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1_: ..PRINT 1 TI, SO 1-10
By using a named format. In the named formats below, paragraph DE
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SHORT AN AU TI TT SO IN LG YR
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ALL AN AU TI TT SO CF IN LG YR PT DE CC AB PA NT
KWIC Context of search terms from the AB paragraph
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For example:
2_: ..P MEDIUM 2,8
BIOSIS Reload December 2003
The information provider has put a great deal of effort into
standardising the indexing of BIOSIS back to 1969, and provided
a complete reload of the data.
In many cases you will now be able to use the same methods of
searching across all years. DataStar has taken the opportunity to
make some improvements, including a different treatment of titles to
allow better deduplication, and standardised database splits.
Enhancements include:
- addition of over 9 million CAS Registry Numbers back to 1969
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Codes, and Concept Codes across all years
- addition of Major Concepts to every citation back to 1969
- addition of over 6,000 Sequence Databank Accession numbers back
to 1989
- enhanced mapping of MeSH disease terms from 1998 to date,
resulting in the addition of many more MeSH terms
- significant enhancement and standardization of bibliographic
data, including re-mapping of publication types across the file
and re-parsing of publication year, volume, issue and
pagination data
- no further distinction between major and minor Concept Codes
- new paragraphs TT (Original Language Title) and CF (Conference
Information): these were previously included in the TI (Title).
As a result, deduplication between BIOSIS and the other
biomedical databases will improve
- new paragraph GN, Gene Name, (previously included in CB)
From March 2007 the coverage has been extended to include
archive records back to 1926. Database coverage is now:
BIOL (1996 to date)
BIYY (1993 to date)
BIXX (1969 to date)
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BI92 (1985-1992)
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Paragraph RN is now just a duplicate of CB and has been kept
to allow existing Alerts to continue to function. Use paragraph
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BIOSIS. Note that the quick code RN= is still
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Descriptor searching can be done across all descriptors:
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will search the Methods & Equipment descriptors and find words
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For a complete guide to the BIOSIS database, search BASE-BIOL in
BASE.
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