|
Cancerlit is the leading source of information on clinical and
experimental oncology.
Cancerlit contains cancer research publications from 1967 to March
2003. It includes all aspects of experimental and clinical cancer
therapy; chemical, viral and other agents that cause cancer;
mechanisms of carcinogenesis; biochemistry immunology, physiology,
and other biology of cancer, both in vivo and in vitro; studies of
mutagens, mutagen testing, and growth factors or other agents that
stimulate cell division. The NLM MeSH headings have been used to
index documents in Cancerlit and the MeSH online thesaurus
is available in Cancerlit too.
Use CANC to answer such questions as:
- what has been published about the carcinogenicity of Aspartame?
- how is nuclear magnetic resonance used in the detection of brain
tumours in children and adolescents?
- is tamoxifen effective in the treatment of metastasis in breast
cancer?
Sources:
Over 3,500 journals are regularly screened for cancer-related
articles; about 200 core journals contribute a large percentage of
the entries. Selected records from Medline are included. In
addition, proceedings of meetings, monographs, theses and government
and symposia reports are also included.
Accession number & update
MEDL-99279699 20010511.
Author(s)
van-Iersel-M-L, Cnubben-N-H, Smink-N, Koeman-J-H, van-
Bladeren-P-J.
Author affiliation
Department of Food Technology and Nutritional Sciences,
Wageningen Agricultural University, The Netherlands.
Title
Interactions of prostaglandin A2 with the glutathione-mediated
biotransformation system.
Source
Biochemical pharmacology {Biochem-Pharmacol}; 57(12):1383-90
1999. ISSN: 0006-2952.
Language
EN.
Publication type
Journal-Article.
Descriptors
BIOTRANSFORMATION;
GLUTATHIONE/*ME (metabolism);
GLUTATHIONE-TRANSFERASE/AI (antagonists & inhibitors), ME
(metabolism);
HUMAN;
ISOENZYMES/AI (antagonists & inhibitors), ME (metabolism);
MELANOMA;
PROSTAGLANDINS-A/*ME (metabolism);
TUMOR-CELLS-CULTURED.
Registry Numbers
EC 2.5.1.- (glutathione S-transferase pi)
EC 2.5.1.18 (Glutathione Transferase)
0 (Isoenzymes)
0 (Prostaglandins A)
13345-50-1 (prostaglandin A2)
70-18-8 (Glutathione).
Abstract
The cylopentenone prostaglandin A2 (PGA2) is known to
inhibit cell proliferation, and metabolism of this compound
thus might be important in controlling its ultimate function.
The glutathione-related metabolism of PGA2 was therefore
investigated both with purified glutathione S-transferase
P1-1 (GSTP1-1) and with IGR-39 human melanoma cells.
Firstly, the irreversible inhibition of human GSTP1-1 and
its mutants C47S, C101S, and C47S/C101S was studied. PGA2
appeared to inhibit...
Journal subset
IM.
Publication year
1999.
Country of publisher
ENGLAND.
Journal code
9Z4.
Entry month
19990611.
Label/description Example
AN NLM accession number 1_: 99279699.AN.
& update 2_: 20010511.AN.
AU Author(s) 3_: VAN-IERSEL-M$.AU.
4_: IERSEL.AU.
5_: ..ROOT IERSEL.AU.
FA First author 6_: VAN-IERSEL-M-L.FA.
IN Author affiliation 7_: WAGENINGEN WITH FOOD.IN.
TI Title 8_: PROSTAGLANDIN.TI. AND
GLUTATHIONE.TI.
TT Title in original lang. 9_: LANGZEITTUMORKONTROLLE.TT.
SO Source 10_: BIOCHEMICAL ADJ
PHARMACOLOGY.SO.
11_: BIOCHEM-PHARMACOL
12_: ..ROOT PHARMACOL.SO.
CM Comment 13_: FEBS.CM.
LG Language 14_: LG=ENGLISH
PT Publication type 15_: PT=JOURNAL-ARTICLE
or 16_: JOURNAL-ARTICLE.PT.
DE MeSH descriptors 17_: TUMOR-CELLS-CULTURED
18_: CELLS WITH CULTURED.DE.
MeSH with Subheading 19_: GLUTATHIONE WITH ME
20_: GLUTATHIONE WITH
METABOLISM
Explode a term 21_: ISOENZYMES#
Find appropriate MeSH terms 22_: ..MESH CELLS
See a term in its TREE
Structure(s) 23_: ..TREE STEM-CELLS
RN CAS Registry numbers 24_: 70-18-8
GS Gene symbol 25_: MYG.GS.
SI Molecular sequence databank 26_: GENBANK.SI.
AB Abstract 27_: HUMAN ADJ NEUROBLASTOMA
ADJ CELL.AB.
Documents with abstracts 28_: ABSTRACT=YES
SB Journal subset 29_: D.SB.
YR Publication year 30_: YEAR=1999
JC Journal code 31_: 9Z4.JC.
ED Entry date 32_: 19990725.ED.
Review articles 33_: REVIEW=YES
Priority (Abridged Index Medicus)
journals 34_: PRIORITY=YES
Documents relating to:
humans 35_: HUMAN=YES
animals 36_: ANIMAL=YES
females 37_: FEMALE=YES
males 38_: MALE=YES
adults 39_: ADULT=YES
children 40_: CHILD=YES
1_: PROSTAGLANDINS
YEAR Year of publication 2_: ..L 1 YEAR>1998
EDATE Entry date (on NCI) 3_: ..L 1 EDATE>20000601
UMONTH Update month (on DataStar) 4_: ..L 1 UMONTH=200105
UDATE Update date (on DataStar) 5_: ..L 1 UDATE>19991115
Tags - HUMAN, ANIMAL, FEMALE, MALE,
ADULT, CHILD, REVIEW, PRIORITY 6_: ..L 1 HUMAN=Y
LG Language 7_: ..L 1 LG=EN, GE, FR
AB Abstract 8_: ..L 1 AB=Y
YEAR Publication year 9_: ..L 1 YEAR>1997.
By paragraph - Title, Source _ :..P TI, SO 1-5
SHORT AN AU IN TI TT SO CM
MEDIUM AN AU IN TI TT SO CM AB
LONG AN AU IN TI TT SO CM AB PT DE RN GS SI JC ED
KWIC Context of search terms from AB paragraph
FREE AN TI TT LG PT DE RN YR ED
ALL AN AU IN TI TT SO CM LG PT DE MJ MN RN GS SI AB SB YR
JC ED
_: ..P SHORT 1-10.
DE - Descriptors - Medical Subject Headings - MeSH Terms
CANCERLIT (since 1980) is indexed according to the same rules as
for MEDLINE, using the Medical Subject Headings (MeSH) of the
National Library of Medicine (NLM). Records dated before 1980 are
not indexed.
Use the NLM's printed MeSH and TREE thesauri or the online MeSH
Thesaurus (..MESH or ..THES; ..TREE or ..EXPL) for
comprehensive searches.
The Descriptor paragraph is double-posted: PROSTAGLANDINS.DE.
retrieves the MeSH term PROSTAGLANDINS, but also the word
PROSTAGLANDINS as a MeSH fragment: PROSTAGLANDINS-A,
PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE, PROSTAGLANDIN-D2, etc.
1_: PROSTAGLANDINS.DE.
To restrict to the single MeSH term PROSTAGLANDINS, qualify
to .W.:
2_: 1.W.
Or use the online MeSH and select terms:
3_: ..MESH PROSTAGLANDINS
THES PROSTAGLANDINS$
R1 # 5 Prostaglandins '63
R2 3 Prostaglandins-A '75
R3 3 Prostaglandins-A-Synthetic '78
R4 3 Prostaglandins-B '78
R5 # 3 Prostaglandins-D '78
R6 # 3 Prostaglandins-E '75
R7 # 3 Prostaglandins-E-Synthetic '78
R8 # 3 Prostaglandins-F '75
R9 # 3 Prostaglandins-F-Synthetic '78
R10 3 Prostaglandins-G '78
R11 3 Prostaglandins-H '78
R12 # 3 Prostaglandins-Synthetic '77
END OF THES
4_: R1
Use hyphen(s) or the WITH operator and qualify to .DE. to search
multi-word terms:
6_: PROSTAGLANDINS-SYNTHETIC.DE.
7_: PROSTAGLANDINS WITH SYNTHETIC.DE.
Qualify to .MJ. to retrieve a MeSH Term as a major topic of the
article.
8_: 7.MJ.
Use a hash (#) to 'explode' MeSH terms (i.e. for retrieval
of all terms in the hierarchy):
9_: PROSTAGLANDINS#
Or use the online MeSH and select terms with the hash mark (#):
10_: ..MESH PROSTAGLANDINS
and select
11_: R1#
Subheadings
Use the WITH operator to link the two-letter subheading
abbreviation, or full subheading to a MeSH term:
12_: PROSTAGLANDINS-SYNTHETIC WITH PD
13_: PROSTAGLANDINS WITH SYNTHETIC WITH PD.DE.
14_: PROSTAGLANDINS WITH SYNTHETIC WITH PHARMACOLOGY.DE.
Use the online MeSH and ..DISPLAY SUBHEADING (or ..D SH) Rn to
retrieve the allowable subheadings:
15_: ..MESH PROSTAGLANDINS
THES PROSTAGLANDINS$
R1 # 5 PROSTAGLANDINS
R2 3 PROSTAGLANDINS-A
R3 3 PROSTAGLANDINS-A-SYNTHETIC
(...)
16_: ..D SH R1
ALLOWABLE SUBHEADINGS FOR
R1 PROSTAGLANDINS
AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
CT contraindications
DF deficiency
DU diagnostic use
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
SE secretion
ST standards
TO toxicity
TU therapeutic use
UR urine
QX 'Quick toxicology' (AE PO TO CT)
17_: R1 WITH PD
18_: R1.W. WITH PD
Pre-exploded Subheadings:
CANCERLIT has some pre-exploded subheadings which allow fast
retrieval of some important subheading groups.
QT - Quick therapy. Contains the subheadings TH (therapy), DT (drug
therapy), RT (radiotherapy), DH (diet therapy) and SU
(surgery).
QD - Quick diagnosis. Contains the subheadings DI (diagnosis), RA
(radiology), RI (radionuclide imaging) and US
(ultra-sonography).
QX - Quick toxicology. Contains the subheadings AE (adverse
effects), PO (poisoning), TO (toxicology) and CT
(contra-indications).
1_: INTESTINAL-NEOPLASMS# WITH QT
This gives the same result as but is faster than:
2_: INTESTINAL-NEOPLASMS# WITH (TH DT SU RT DH).MJ.
Quick-Search:
Quick-Search is a fast and easy method of retrieving Subheadings
linked to MeSH terms and pre-exploded subheadings. The Subheadings
can only be Quick-Searched as abbreviations. Precede your search
with QS:
3_: QS BREAST-NEOPLASMS# WITH (PP CH DT)
4_: QS BREAST-NEOPLASMS# WITH QD
Quick-Search also works very well in combination with the online
MESH and TREE, which saves time and typing:
5_: ..MESH NEOPLASMS
THES NEOPLASMS$
R1 # NEOPLASMS
R2 # ABDOMINAL-NEOPLASMS
R3 # NEOPLASMS-ADIPOSE-TISSUE
R4 # NEOPLASMS-ADNEXAL-AND-SKIN-APPENDAGE-NON-MESH
(...)
R17 # 2 BREAST-NEOPLASMS
6_: ..SET TREE 9,9
7_: ..TREE R17
T1 # . ENDOCRINE-DISEASES
T2 # .. BREAST-DISEASES
T3 ... BREAST-NEOPLASMS
T4 # . NEOPLASMS
T5 # .. NEOPLASMS-BY-SITE-NON-MESH
T6 # ... BREAST-NEOPLASMS
T7 .... MAMMARY-NEOPLASMS
T8 .... MAMMARY-NEOPLASMS-EXPERIMENTAL
8_: QS (R17 T7 T8) WITH (PP CH DT)
Search statements, including those using Quick-Search may be saved
for later re-execution and as Alerts.
YR - Year of publication
It is often useful to restrict a search over a range of years:
1_: PROSTAGLANDINS WITH SYNTHETIC.DE.
2_: 1 AND (1998 OR 1999).YR.
Or use the ..LIMIT command:
3_: ..L 1 YEAR>1997
ED - Entry date
This gives the year and month the citation was entered into the
NCI computer. It is useful for precisely updating previous search
strategies:
4_: ..L 1 EDATE>20010306
retrieves all citations added to the database after March 6 2001.
Search options:
..SET PLURALS ON and ..SET MEDWORD ON can be selected in CANC.
..RANK and ..MAP are available in the AU, SO, DE and RN
paragraphs.
Guides:
The guide to CANC is published in the DataStar Biomedical Manual,
Berne, and online in BASE - search BASE-CANC.
Search aids
The following hard copy search aids are highly recommended:
. Medical Subject Headings - Annotated Alphabetic List
. Medical Subject Headings - TREE Structures
. Permuted Medical Subject Headings
The Medical Subject Headings (MeSH), Subheadings and the List of
Serials are available online in database MVOC (MeSH
Vocabulary).
The hard copy search aids are available from:
1. Hans Huber AG, L³nggass-Strasse 76, 3000 Berne 9, Switzerland,
Tel: +41 31 300 4535, email: scheidegger@hanshuber.com
http://www.mesh.ch
2. The British Library, Help Desk, Turpin Distribution Services,
Blackhorse Road, Letchworth Herts SG6 1HN, Tel: 01462 672555,
Fax: 01462 480947 email: custservturpin@turpinltd.com
3. AIRS (American Information Retrieval Service),
5 Elvaston Mews, London SW7 5HY. Tel: +44 207 225 2799
4. NTIS (National Technical Information Services), US Department
of Commerce, 5285 Port Royal Road, Springfield, Virginia
22161, USA; (or the NTIS Bureaux in Europe)
http://www.ntis.gov
Note: All publications listed above are edited and published
annually by NLM, to include the new Medical Subject
Headings. It is important to buy a new set each year, so
you are aware of the new terminology used by the NLM.
Generally, they are available in December for use in the
following year.
NATIONAL LIBRARY OF MEDICINE
MEDLINE is a registered trademark of the National Library of
Medicine. For the Dialog Corporation's Redistribution and
Archive Policy, go to Medline (..C MEDL) and type ..HELP ERA
and ..PRICE MEDL.
The following terms and conditions also apply.
NLM represents that the data provided ... were formulated with a
reasonable standard of care. Except for this representation ...,
NLM makes no representation or warranties, expressed or implied.
This includes, but is not limited to, any implied warranty of
of merchantability or fitness for a particular purpose, with respect
to the NLM databases, and NLM specifically disclaims any such
warranties and representations.
The duplication, resale, or redistribution of data obtained under
Dialog's Agreement with the NLM must conform to fair use guidelines
and U.S. international copyright law.
Unless otherwise prohibited, organizations or institutions
may download small amounts of NLM-produced citations for
redistribution. For MEDLINE, this is about 1,000 per month or 12,000
records for each year of coverage. Since NLM makes corrections
and enhancements to and performs maintenance on these records
at least annually, users should plan to replace or correct the
records once a year to ensure that they are still correct and
usable as a group.
NLM databases are produced by a U.S. government agency and as such
the contents are not covered by copyright domestically. They may
be copyrighted outside U.S. Some NLM produced data is from
copyrighted publications of the respective copyright claimants.
Users of the NLM databases are solely responsible for compliance
with any copyright restrictions and are referred to the
publication data appearing in the bibliographic citations, as well
as to the copyright notices appearing in the original publications,
all of which are incorporated by reference. Users should consult
legal counsel before using NLM-produced records to be certain that
their plans are in compliance with appropriate laws.
All records must be identified as being derived from NLM
databases.
Back to the Datasheet Index Page
© 2009 Dialog LLC All Rights Reserved
|