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Drug Information Full Text presents 1500 complete evaluative drug
descriptions on essentially all drug products (50,000+) available in
the US.
DIFT contains monographs on drugs marketed in the US and some
abbreviated descriptions on investigational injectable drugs. For
each drug you will find trade names, generic name, manufacturer,
therapeutic classification, and CAS registry number and detailed
sections on: chemistry, pharmacology, mechanism of action,
pharmacokinetics, uses, cautions, acute and chronic toxicity, drug
interactions, dosage and administration, preparations and references
to the literature.
All those working in the pharmaceutical and allied industries, such
as doctors, pharmacists, nurses and medical information officers
will find DIFT an invaluable information resource.
Use DIFT to answer questions such as:
- Are there any side effects known for the antihistamine drug -
Seldane?
- What drugs can be used to treat 'panic disorder'?
- What drugs does Ciba have on the market?
- When Thiopental is administered as a drug added to large volume
parenteral therapy, can Amikacin also be added to the injection?
Sources:
Drug Information Full text is the online version of two print
publications - the American Hospital Formulary Service Drug
Information and the Handbook on Injectable Drugs. The online version
also contains concept tags and references used to write.
Accession number & update
00385002 20040511.
Title
Ampicillin.
Synonyms
Aminobenzylpenicillin; d(-)-Alpha-Aminobenzylpenicillin;
Ampicillin A; Sodium Ampicillin; Aminobenzylpenicillin Trihydrate;
Ampicillin.
Tradenames
Principen(R) (Geneva); Principen(R) (Geneva); Principen(R)
(Geneva); Ampicillin Sodium for Injection (Geneva);
Ampicillin sodium Piggyback (Geneva); Ampicillin Sodium ADD-
Vantage(R) (Geneva).
Investigational name: AY-6108; BRL 1341; NSC-528986
AY-6108; BRL 1341; NSC-528986
Chemical name
(2S-((2alpha,5alpha,6beta(S*)))))-6-((Aminophenylacetyl)amino)-
3,3-dimethyl-7-oxo-4-thia-1-azabicyclo((3.2.0))heptane-2-
carboxylic acid; (2S-(2Alpha,5Alpha,6Beta(S*)))-6-
((Aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
(3.2.0) heptane-2-carboxylic acid monosodium salt;
2S-(2Alpha,5Alpha,6Beta(S*)))-6-((Aminophenylacetyl)amino)-
3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-
carboxylic acid trihydrate.
CAS Registry number
69-53-4; 69-52-3; 7177-48-2.
Molecualr formula
C16H19N3O4S; C16H19N3O4S-Na; C16H19N3O4S-3H2O.
Source
AHFS Drug Information.
Therapeutic classes
8-12-16 Penicillins.
Cross references
00385902.AN. Aminopenicillins General Statement.
Entry date
20031017. New.
Length
76,531 Characters, approximately 45 PC screens.
Table of contents
INTRODUCTION TX(1)
USES TX(2)
DOSAGE AND ADMINISTRATION TX(3)
CAUTIONS TX(4)
SPECTRUM TX(5)
PHARMACOKINETICS TX(6)
CHEMISTRY TX(7)
PREPARATIONS TX(8)
REFERENCES TX(9).
Text
1 OF 10.
(Concept tags 11 Chemical Description 20 Therapy, Pharmacotherapy,
Microbiology 26 Microbiology (General)) Ampicillin is an
aminopenicillin antibiotic. 64)76)77).
More information on Uses in General Statement monograph (see
00385902.AN.)
2 OF 9
USES
(Concept tag 22 Therapy/Use) Ampicillin shares the uses of other
aminopenicillins and is used principally for the treatment of
infections caused by susceptible gram-negative bacteria (e.g.
Haemophilus influenzae, Escherichia choli, Proteus mirabilis.
3 OF 9
DOSAGE AND ADMINISTRATION
Reconstitution and Administration
Concept tag 57 Administration/Route) Anhydrous ampicillin (no
longer commercially available in the US) and ampicillin
trihydrate are administered orally, 42).43).44).45).46).47).
48).49).50).1420). and ampicillin sodium may be given orally
with meals, maximum absorption is achieved when the drug is
given 1 hour before, or 2 hours after meals.43).
...etc
Labels/description Example
AN Accession number 1_: 00385002.AN.
& update 2_: 20040511.AN.
TI Title 3_: AMPICILLIN.TI.
SY Synonyms, etc (includes SN, 4: AMINOBENZYLPENICILLIN.SY.
GN, TN, IV)
SN Synonyms 5_: AMINOBENZYL$.SN.
GN Generic name 6_: CILOSTAZOL.GN.
TN Tradenames 7_: PRINCIPEN.TN.
IV Investigational name 8_: AY-6108.IV.
- or use .SY. for all types
of name - 9_: PRINCIPEN.SY.
10_: AMINOBENZYLPEN$.SY.
CN Chemical name 11_: AMINOPHENYLACETYL.CN.
RN CAS Registry Number 12_: 69-53-4.RN.
MF Molecular formula 13_: C16H19N3O4S.MF.
SO Source: two options -
AHFS Drug Information 14_: AHFS.SO.
Handbook on Injectable Drugs 15_: INJECTABLE.SO.
CC Therapeutic classes 16_: PENICILLINS.CC.
17_: 8-12-16
18_: 8-12#
19_: 8#
XR Cross references 20_: 00385902.AN.
ED Entry date 21_: 20031017.ED.
LE Length - Display only -
TC Table of contents 22_: USES.TC.
For a list of section heads 23_: ..ROOT SH=
TX Text 24_: AMPICILLIN WITH INJECTION.TX.
25_: 330 WITH RECONSTITUTION
26_: AMPICILLIN WITH STABILITY.TX.
CR Cited references 27_: NOVARTIS.CR.
CP Copyright statement 28_: PHARMACISTS.CP.
YR Publication year
(search only) 29_: YEAR=2003.
1_: ELIMINATION
UMONTH Update month YYYYMM 2_: ..L 1 UMONTH>200302
UDATE Update date YYYYMMDD 3_: ..L 1 UDATE>20030215
ED Entry date 4_: ..L 1 ED>20031015.
By paragraph _: ..P TI, SY 1-10
SHORT AN TI SY SO ED OC LE
MEDIUM AN TI SY RN SO ED OC LE TC
LONG AN TI SY RN SO CC ED OC LE TC HITS
ALL AN TI SY (SN GN TN IV) CN RN MF SO CC XR ED OC LE TC TX CR CP
YR
HITS All paragraphs where search terms occur
FREE AN TI RN SO OC LE TC
_: ..P MEDIUM 1-5.
Full text printing in DIFT:
Print title and occurrences to check the relevance of the document
and obtain a list of paragraphs where search terms appear, e.g.:
1_: ..P TI, OC 1
Then select either specific paragraphs:
2_: ..P TX(1,2-4) 1
or all paragraphs where search terms occur with HITS
3_: ..P HITS 1
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