|
The Derwent Veterinary Drug file covers the worldwide literature on
veterinary drug and vaccine development.
The database is available to subscribers only. To become a
subscriber, you should contact Derwent Information Ltd direct.
DVDU includes citations and abstracts on the evaluation and use of
veterinary drugs and vaccines in animals, in particular on
prevention and treatment of animal diseases, growth promotion, and
breeding manipulation, adverse effects, toxicology and analysis of
drugs and their interactions.
Each document contains an abstract written by a Derwent subject
specialist and is accompanied by extensive indexing allowing highly
specific retrieval. DVDU will be of particular interest to
information specialists and scientists involved with animal health
pharmaceuticals.
Use DVDU to find:
- references to treatment of Ehrlichia risticii in horses
- documents studying the effects of anabolic implants on carcass
characteristics in cattle
- references to the interaction between tiamulin and tylosin papers
- find all papers on paracetamol poisoning in rabbits and its
treatment
- information on the anaesthetic effect of saffan in cats
Sources:
Approximately 1,200 journal titles from around the world in more
than 20 different languages. Conference proceedings are also
covered.
Accession number & update
91-61458 910000.
Occurrences
PARAGRAPH
AN (1)
Title
The Efficacy of Danofloxacin in the Therapy of Pneumonia
Associated with Pasteurella Species in Housed Calves.
Author(s)
Grimshaw-W-T-R, Giles-C-J, Cooper-A-C, Shanks-D-J.
Source
Dtsch-Tieraerztl-Wochenschr (97, No. 12, 529-32, 1990) Coden:
DTTIAF.
Publication year
1990.
Company name
Pfizer.
Location
Sandwich, UK.
Language
EN.
Thematic groups (83-91)
Therapeutics (T).
Section
3 Antibacterials & Bacteria; 9 Large (&Farm) Animal Therapy.
Abstract (A1 A2)
The efficacy of i.m. danofloxacin (DAN) in the treatment of
pneumonia associated with Pasteurella multocida and P.
haemolytica in housed cattle in Germany and Italy was examined.
DAN therapy was compared with trimethoprim/sulfa combinations in
the form of trimethoprim/sulfadoxine (Duoprim, Coopers-Anim
.Health; Borgal, Hoechst) or trimethoprim/sulfadiazine (Norodine,
Bayer). The clinical response to treatment with DAN was superior
to that seen in cattle treated with trimethoprim/sulfa, with
lower rectal temperatures. MIC values indicated that all isolates
of P. multocida and P. haemolytica were sensitive to DAN and the
majority were sensitive to trimethoprim/sulfa; resistance to
oxytetracycline, amoxicillin and erythromycin was prevalent.
73 Calves with clinical signs of acute pneumonia and increased
rectal temperatures were treated with 1.25 mg/kg DAN, i.m. ; 77
were treated with 4-20 mg/kg trimethoprim/sulfa drugs i.m. All
animals were treated once daily for 3 consecutive days or 5 days
depending on the response to treatment. DAN-treated calves had
lower rectal temperatures than those treated with trimethoprim
/sulfa drugs; these differences became significant on the 2nd and
3rd days of therapy. 24 Hr after the 3rd injection, 53 (69%) of
trimethoprim/sulfa-treated calves requiring 2 further days of
therapy, compared with only 39 (53%) of the DAN-treated calves.
24 Hr after completion of therapy, 77% of DAN-treated calves had
rectal temperatures of less than 39.5 deg and 71% judged clinical
normal, compared with 58% of trimethoprim/sulfa-treated calves
with 55% judged as clinically normal. During the post-treatment
period 21 (29%) DAN-treated calves met the re-treatment criteria
compared with 28 (36%) of trimethoprim/sulfa-treated calves. 1
Trimethoprim/sulfa-treated calf died before completion of
treatment. MIC values of P. haemolytica and P. multocida strains
isolated indicated that they were sensitive to DAN (MIC90 of 0.25
ug/ml). Only 6 (11%) of the P. haemolytica and 2 (5%) of the P.
multocida strains isolated were resistant to trimethoprim/sulfa
drugs (MIC greater than 2.0 ug/ml). MIC90 values of
oxytetracycline, amoxicillin and erythromycin indicated that
resistance to these agents among Pasteurella spp. were prevalent.
3 Fig. 1 Tab. 21 Ref. (VDM)
Pfizer Central Research, Sandwich, Kent CT13 9NJ, England.
Common terms
IN-VITRO/FT; PASTEURELLA/FT; MULTOCIDA/FT; HAEMOLYTICA/FT; MIC
/FT; BACT/FT; GRAM-NEG/FT.
Link terms
1 OF 7.
*01* DANOFLOXACIN/PH; DANOFLOXACIN/TR; PASTEURELLOSIS/TR;
INFECTION-BACT/TR; PNEUMONIA/TR; ANTISEPTICS/FT; ANTISEPTIC/FT;
IN-VIVO/FT; NEW/FT; CATTLE/FT; QUINOLINE/FT; CYCLOPROPANE/FT; AH-
LINKED-CX/FT; AMINOACID/FT; KETOACID/FT; ARYLFLUORIDE/FT; KETONE-
CYCLIC/FT; ARYLKETONE/FT; ARYLAMINE/FT; PYRROLIDINE/FT;
PIPERAZINE/FT; BRIDGE-STRUCT/FT; BH-LINKED-CX/FT; DRUG-COMPARISON
/FT; FARM-ANIMAL/FT; PH/FT; TR/FT; 02A/G1; 02H/G1; 022/G1; 031
/G1; 032/G1; 04A/G1; 052/G1; 057/G1; 06H/G1; 062/G1; 065/G1; 071
/G1; 072/G1; 08A/G1; 080/G1; 094/G1; 10A/G1; 10H/G1; 100/G1; 102
/G1; 108/G1; 122/G1; 131/G1; 138/G1; 17H/G1; 170/G1; 23H/G1; 232
/G1; 237/G1; 25H/G1; 250/G1; 257/G1; DANOFLOXA/RN.
2 OF 7.
*02* TRIMETHOPRIM/PH; TRIMETHOPRIM/TR; DUOPRIM/PH; DUOPRIM/TR;
NORODINE/PH; NORODINE/TR; BORGAL/PH; BORGAL/TR; BAYER/FT; HOECHST
/FT; COOPERS-ANIM-HEALTH/FT; PASTEURELLOSIS/TR; INFECTION-BACT
/TR; PNEUMONIA/TR; ANTISEPTIC/FT; COMB-PREP/FT; IN-VIVO/FT;
CATTLE/FT; DRUG-COMPARISON/FT; FARM-ANIMAL/FT; ANTISEPTICS/FT;
FOLATE-ANTAGONISTS/FT; 738-70-5/FT; TRIMETHOP/RN; PH/FT; TR/FT.
3 OF 7.
*03* SULFORMETOXINE/TR; SULFORMETOXINE/PH; DUOPRIM/TR; DUOPRIM
/PH; BORGAL/TR; BORGAL/PH; COOPERS-ANIM-HEALTH/FT; HOECHST/FT;
PASTEURELLOSIS/TR; INFECTION-BACT/TR; PNEUMONIA/TR; ANTISEPTIC
/FT; COMB-PREP/FT; IN-VIVO/FT; CATTLE/FT; DRUG-COMPARISON/FT;
FARM-ANIMAL/FT; ANTISEPTICS/FT; 2447-57-6/FT; SULFORMET/RN; TR
/FT; PH/FT.
4 OF 7.
*04* SULFADIAZINE/TR; SULFADIAZINE/PH; NORODINE/TR; NORODINE/PH;
BAYER/FT; PASTEURELLOSIS/TR; INFECTION-BACT/TR; PNEUMONIA/TR;
ANTISEPTIC/FT; IN-VIVO/FT; COMB-PREP/FT; CATTLE/FT; DRUG-
COMPARISON/FT; FARM-ANIMAL/FT; ANTISEPTICS/FT; 68-35-9/FT;
SULFADIAZ/RN; TR/FT; PH/FT.
5 OF 7.
*05* OXYTETRACYCLINE/PH; ANTIBIOTIC/FT; RESISTANCE/FT;
ANTIBIOTICS/FT; 79-57-2/FT; OXYTETRAC/RN; PH/FT.
6 OF 7.
*06* AMOXICILLIN/PH; ANTIBIOTIC/FT; RESISTANCE/FT; ANTIBIOTICS
/FT; 26787-78-0/FT; AMOXICILL/RN; PH/FT.
7 OF 7.
*07* ERYTHROMYCIN/PH; ANTIBIOTIC/FT; RESISTANCE/FT; ANTIBIOTICS
/FT; 114-07-8/FT; ERYTHROMY/RN; PH/FT.
Labels/description Example
AN Accession number 1_: 1991-61458.AN.
& update - see Limit options -
OC Occurrences - Display only -
TI Title 2_: EFFICACY ADJ DANOFLOXACIN.TI.
AU Author(s) 3_: COOPER-A$
SO Source 4_: DTSCH-TIERAERZTL-WOCHENSCHR
5_: DTTIAF
YR Publication year 6_: YEAR=1990
CO Company name 7_: PFIZER.CO.
LO Location 8_: UK.LO.
LG Language 9_: EN.LG.
SC Section 10_: '3'.SC.
11_: BACTERIA.SC.
AB Abstract (A1 A2) 12_: DANOFLOXACIN
A1 Abstract summary 13_: PNEUMONIA WITH CATTLE.A1.
A2 Abstract extension 14_: CALVES WITH PNEUMONIA.A2.
DE Descriptors (CT LT) 15_: DANOFLOXACIN.DE.
16_: HAEMOLYTICA.DE.
CT Common Terms 17_: IN-VITRO.CT.
LT Link Terms 18_: PNEUMONIA WITH TR.LT.
19_: PNEUMONIA-TR.LT.
AY= Accession year 1_: AY=1993
YEAR= Publication year 2_: YEAR=1992
LG= Language* 3_: LG=EN
SC= Section 4_: SC=3
* Note: English, Russian, Japanese, French, German only are
available as standard quick codes.
1_: ANTIBIOTICS
YEAR Publication Year YYYY 2_: ..L 1 YEAR WL 1991,1993
UDATE Update date YYYYMMDD 3_: ..L 1 UDATE LT 19970726
UMONTH Update month YYYYMM 4_: ..L 1 UMONTH>199305
AY Accession year YYYY 5_: ..L AY=1993.
By paragraph - author, title: _: ..P AU, TI 1-20
SHORT AN OC TI AU SO
MEDIUM AN OC TI AU SO CO LO A1
LONG AN OC TI AU SO CO LO AB
ALL AN OC TI AU SO YR CO LO LG TG SC AB DE (CT LT)
FREE AN OC TI YR LG DE (CT LT)
_: ..P LONG 1,7,11.
Descriptor searching:
A standard name (e.g. INN, USAN, laboratory code) is used to
identify each drug. In addition the pharmacological classification
and the drug activity are also indexed. Search as:
1_: ANTIBIOTICS.DE.
2_: TYLOSIN.DE.
Or for a more specific search use descriptor with a drug or disease
two-letter qualifier and link using the WITH operator.
3_: PARACETAMOL WITH PH.DE.
A full list of Drug and Disease Qualifiers is available online in
BASE-DVDU.
Search Options:
..SET PLURALS ON and ..SET MEDWORD ON can be selected in DVDU
Guides:
The guide to the Derwent Veterinary Drug file ia available in the
BASE database - search BASE-DVDU.
The Terms and Conditions cover data obtained from the following
databases:
- Derwent Crop Protection File (DCPU)
- Derwent Crop Protection Registry (DCRR)
- Derwent Drug File (DDFU)
- Derwent Drug Registry (DDRR)
- Derwent Veterinary Drug File (DVDU)
- Derwent Biotechnology Abstracts (DWBA)
The online use by customers of the databases ("Derwent databases")
of Derwent Publications Limited ("Derwent") and all data obtained
from Derwent databases is subject to the following terms and
conditions:
1. All data obtained from Derwent databases and all copyright
therein is and shall at all times remain the property of Derwent.
2. All data obtained from Derwent databases is to be treated as
strictly confidential and may not be copied, duplicated,
translated into any language or in any way reproduced without the
prior written consent of Derwent.
3. The customer undertakes and agrees that:
a) any searches against Derwent databases will be conducted by
the customer's employees for the customer's internal use only,
and the results of such searches will not be disclosed or
transmitted to any third party, except as permitted in
paragraphs 3b - 3g below;
b) if the customer wishes to conduct searches on behalf of a
third party, the customer will notify Derwent and obtain
Derwent's written consent; searches on behalf of a third party
will not be permitted unless and until permission has been
granted by Derwent in writing;
c) any search conducted on behalf of a third party must be
performed directly by the customer's employees and will be
solely for that third party;
d) prior to any search being conducted on behalf of a third party
the customer will ensure that the third party undertakes to
the customer and Derwent that the results of such search are
for that third party's own internal use only;
e) whenever the customer obtains data from Derwent databases for
a third party, the customer shall notify that third party in
writing of the ownership by Derwent of the data concerned and
all copyright therein;
f) copies of online and offline prints must be conspicuously
marked:
"FOR INTERNAL USE ONLY DERWENT PUBLICATIONS LIMITED 1991",
g) the term "third party" does not refer to a patent issuing
authority, such as Patent Office, where data obtained from
Derwent databases is required by law or regulation in the
normal conduct of the patent issuing authority's day-to-day
business.
4. Output from online searches may be stored temporarily in
electronic form for a maximum period of three months for the
purpose of editing or reformatting the search results. For longer
term storage, a Downloading Agreement with Derwent must be
completed and the appropriate fees paid.
5. In the event of a breach by the customer, its employees or any
third party, of any of these terms and conditions Derwent shall
be entitled to terminate the customer's right of access to
Derwent databases immediately without notice.
6. Derwent shall not in any circumstances be liable or responsible
for the completeness or accuracy of any data comprised in the
Derwent databases nor for the transmission of such data and will
not be liable for any indirect, consequential or economic loss of
profit resulting directly from the use by the customer or any
third party of such data.
7. The customer will not assign any of its rights under these terms
and conditions in whole or in part without the prior written
consent of Derwent.
8. The invalidity, illegality or unenforceability in whole or in
part of any of these terms and conditions shall not affect the
validity, legality and enforceability of the remaining terms and
conditions.
9. These terms and conditions shall override and prevail over any
other terms and conditions in any document or other communication
used by the customer in effecting its subscription to the Derwent
databases.
10. These terms and conditions shall be governed by and construed in
accordance with English law.
Back to the Datasheet Index Page
© 2008 Dialog DataStar
|