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IMS Health Patents International is the most comprehensive source of
evaluated product patent family data for pharmaceuticals worldwide.
IPIP contains product patent family data for over 3,000 commercially
significant drugs. It is the only product patent database that
allows access by generic or trade name which contains commercially
significant drugs (including those already marketed or in Phase III
clinical trials or above). Each document gives details of drug name,
therapeutic class, registry numbers and patent data including
estimated expiry dates, priority details, originator and originator
country.
Use IPIP to:
- find which beta-blockers come off patent in the UK between 1999
and 2005
- track down ACE inhibitors which originated in Japan
- locate the owner of a particular drug, and find where it is
patented.
- determine the product patent for cimetidine in the UK and US
Sources:
IPIP is compiled from IMS databases e.g. R&D Focus and MIDAS,
original patent specifications, Patent Office journals, and various
online and hard copy secondary sources of patent and chemical
information.
Accession number & update
0002406 930311.
Patent title
CLAVULANIC ACID. Method of use; Equivalent to product.
Synonyms
Generic names: CLAVULANIC ACID; POTASSIUM CLAVULANATE (British
approved name); CLAVULANIC ACID (International Nonproprietary
name); CLAVULANATE POTASSIUM (United States adopted name);
Trade name(s): SPEKTRAMOX; AUGMENTIN; TIMENTIN
Laboratory code: MM 14151.
CAS registry numbers
58001-44-8 2R-(2alpha,3Z,5alpha) , clavulanic acid;
98524-36-8 2R-(2alpha,3Z,5alpha) , calcium salt (2:1);
98402-82-5 2R-(2alpha,3Z,5alpha) , magnesium complex;
61177-46-6 2R-(2alpha,3Z,5alpha) , monoammonium salt;
61177-44-4 2R-(2alpha,3Z,5alpha) , monolithium salt;
61177-45-5 2R-(2alpha,3Z,5alpha) , monopotassium salt;
60802-63-3 2R-(2alpha,3E,5alpha) , monosodium salt;
57943-81-4 2R-(2alpha,3Z,5alpha) , monosodium salt;
61177-42-2 2R-(2alpha,3Z,5alpha) , barium salt;
67529-22-0 2R-(2alpha,3Z,5alpha) , magnesium salt (2:1);
74469-00-4 2R-(2alpha,3Z,5alpha) , monopotassium salt, mixture
with amoxicillin;
79198-29-1 2R-(2alpha,3Z,5alpha) , mixture with amoxicillin;
86482-18-0 2R-(2alpha,3Z,5alpha) , mixture with ticarcillin;
70052-53-8 2R-(2alpha,3Z,5alpha) , monosodium salt, mixture with
mezlocillin;
98445-50-2 no stereochemistry indicated, aluminium complex.
Therapeutic classes
Antibiotics; J01.
Patent assignee
Beecham (UK)
Corporation: SmithKline Beecham (UK)
Country
USA.
Patent no. & pub. date
Patent number: 4529720
Publication date: 19850716.
Priority information
UK no 17410
Priority date: 20 April 1974.
Related priority info.
UK no 27715; UK no 43651; UK no 53525
Related priority date(s): 21 June 1974; 9 October 1974; 11
December 1974.
Expiry date and comments
Estimated expiry date: July 2002
Extensions possible.
Tradenames
AUGMENTIN; TIMENTIN.
General comments
Glaxo and Beecham synthesised clavulanic acid and its salts
independently. Beecham obtained patent rights in most countries,
as the Beecham patents have the earliest priority date. However,
in the USA Glaxo obtained product patent rights to the potassium
salt (US 4367175), the lithium salt (US 4490294) and the sodium
salt (US 4490295) of clavulanic acid. All rights to these patents
have been reassigned from Glaxo to Beecham - see separate entry
for the Glaxo patents. Beecham has claims to synergistic
compositions of clavulanic acid in the following related patents:
Austria 353407 (appln 77/2053); Canada 1055395; East Germany
132297; Sweden 446687 (appln 78/11201); West Germany 2559411; USA
nos 4525352, 4525353, 4526783, 4560552.
Country comments
USA patent no 4529720 is a method of use patent. Beecham has
claims to compositions of potassium clavulanate with amoxicillin
trihydrate in US 4537887, published 27 August 1985, normal expiry
27 August 2002. Beecham has claims to compositions of potassium
clavulanate with amoxicillin trihydrate with enhanced stability
in US 4441609, published 10 April 1984, normal expiry 10 April
2001.
Labels/description Example
AN Accession number 1_: 0002406.AN.
& update - see Limit options -
TI Patent title 2_: CLAVULANIC ADJ ACID.TI.
SY Synonyms 3_: AUGMENTIN.SY.
RN CAS registry numbers 4_: 61177-44-4
5_: AMOXICILLIN.RN.
CC Therapeutic classes 6_: ANTIBIOTICS.CC.
7_: J01.CC.
PA Patent assignee 8_: BEECHAM.PA.
CN Country 9_: USA.CN.
PN Patent no. & publ. date 10_: 4529720.PN.
AP Patent application info. 11_: '78' ADJ 11200
FD Patent filing date 12_: 19750418.FD.
PR Patent priority info. 13_: UK WITH APRIL.PR.
RP Related priority info. 14_: UK WITH JUNE.RP.
EX Expiry date and comments 15_: 2002.EX.
TN Tradenames 16_: AUGMENTIN.TN.
T1 General comments 17_: RELATED ADJ PATENTS.T1.
T2 Country comments 18_: SWEDEN OR SWEDISH.T2.
CC Therapeutic class codes 1_: CC=C06A
PR Priority date 2_: PR=NA
(also for PD Publication date, FD Filing date, AP Application
date, EX Expiry date search '=NA ' to remove documents where no
date available when LIMITing to dates using LESS THAN.
1_: ANTIBIOTICS.CC.
PR Priority date YYYYMMDD 2_: ..L 1 PR<19750101
PD Publication date YYYYMMDD 3_: ..L 1 PD>19880607
FD Filing date YYYYMMDD 4_: ..L 1 FD=19750418
AP Application date YYYYMMDD 5_: ..L 1 AP>19801010
EX Expiry date YYYYMMDD 6_: ..L 1 EX EQ 19970101,
UDATE Update date YYYYMMDD 7_: ..L 1 UDATE>19990526
UMONTH Update month YYYYMM 8_: ..L 1 UP WL 199904,199905.
SHORT AN TI SY CC PA CN TN
MEDIUM AN TI SY CC PA CN PN AP EX TN T2
LONG AN TI SY RN CC PA CN PN AP FD PR RP EX TN TX
ALL AN TI SY RN CC PA CN PN AP FD PR RP EX TN TX
FREE AN TI CC
Example: ..P SHORT 1-10
Or by paragraph: ..P TI, SY, PN 5-10,11.
Printing documents:
To see complete product patent family information use LONG format.
To see only country specific information use MEDIUM format
Search Options:
..SET PLURALS ON and ..SET MEDWORD ON can be selected in IPIP.
Guides:
Guide to IPIP appears in Biomedical Manual and online in BASE -
search BASE-IPIP.
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