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Content:
Pharm-line is produced by the regional and national Medicines
Information Centres of the United Kingdom National Health
Service.
The original focus of Pharm-line was on clinical pharmacy, with
relevant papers from medical and pharmacy journals abstracted
to provide a single database to meet the requirements of a
local hospital's Medicines Information Centre. In view of the
wide availability of other databases with content in this area,
it was decided some time ago that this objective was no longer
appropriate and the emphasis has been gradually changed towards
providing evidence to support pharmacy, prescribing and
medicines management in both primary and secondary care. This
trend will continue, informed by surveys of subscribers and of
other users of medicines information. A further development in
recent years has been the indexing of papers presented at
pharmacy-related conferences in the UK, continental Europe, the
USA and Australia.
Papers referring principally to animal or laboratory studies
are excluded.
Pharm-line is produced jointly by a working party of drug
information specialists at the UK National Health Service's
(NHS) Medicines Information Centres. The aim of the working
party is to offer a contextually defined and goal-directed
database as well as rapid access to published drug literature
through Pharm-line.
Currently some 11-12,000 documents are loaded each year. Some
90% of documents in the database contain abstracts - either
written by the author, or prepared by specialist abstractors.
Use LINE to answer questions like:
- What are the effects of pharmacists' actions (especially
discharge counselling) on patients' compliance?
- What reports have been published of pregnancy following
failure of oral contraceptives due to interactions with other
drugs?
- What measures have been discussed to regulate drug supply via
the Internet?
- What systematic reviews have been published comparing the
different 'triptans'?
- What problems have been reported with use of
phenylpropanolamine in patients on antihypertensives?
Sources:
Approximately 100 English-language periodicals (not necessarily
UK-focused) are selectively abstracted and indexed for Pharm-
line, together with relevant conference proceedings. In
addition to original articles, letters to the editor (if they
contain new information or comment on a previous original
report), reviews, news items and editorials are also included.
AN - Accession number & update
0000534089 20051010.
TI - Title
Daptomycin pharmacokinetics and safety following
administration of escalating doses once daily to healthy
subjects.
SO - Source
Antimicrobial Agents and Chemotherapy, {Antimicrob-Agents-
Chemother}, Apr 2003, vol. 47, no. 4, p. 1318-1323, ISSN:
0066-4804.
AU - Author(s)
Dvorchik-B-H, Brazier-D, DeBruin-M-F, Arbeit-R-D.
AB - Abstract
Phase I, randomised, double-blind study in 24 volunteers.
Measured half-life, volume of distribution, systemic
clearance and urinary excretion. No serious adverse effects.
DE - Descriptors
Volunteers-human; Volume-of-Distribution; Pharmacokinetics;
Adverse-Effects; Drug-Administration-Schedule; Plasma;
Clearance-drug; Half-Life; Excretion-drug; Daptomycin;
Patient-Safety.
LG - Language
English.
AT - Article type
Randomised-Controlled-Trial.
AV - Availability
Abstract link:
<http://aac.asm.org/cgi/content/abstract/47/4/1318>.
YR - Publication year
2003.
DT - Publication date
20030400.
ED - Entry date
20040610.
AN - Accession number & update
0000523397 20051010.
TI - Title
Untitled.
TT - Title in original lang.
Réaction d'hypersensibilité à l'abacavir ou hépatite
syphilitique?
SO - Source
Presse Medicale, {Presse-Med}, Oct 2003, vol. 32, no. 33,
p. 1557-1558, ISSN: 0755-4982.
AU - Author(s)
Dumouchel-Champagne-H, Bouhour-D, Ferry-T, et al.
AB - Abstract
Case report of an HIV-seropositive homosexual patient where
liver function changes and an exanthematous rash were
observed 15 days after introduction of treatment with
abacavir (Trizivir). Given the hepatitis and cutaneous
eruption, a hypersensitivity reaction to abacavir was
suspected. Treatment was stopped but no improvement was
observed. Finally, syphilitic hepatitis syphilitique was
diagnosed, and improvement was seen with benzathine-
penicillin and Trizivir was reintroduced without problems.
Clinicians should note the possibility of syphilitic
hepatitis, accompanied or not by cutaneous eruptions.
DE - Descriptors
Abacavir; Venereal-Diseases; Syphilis; Human-
Immunodeficiency-Virus; Homosexuality; Hepatitis; Liver;
Rash; Benzathine-Penicillin.
MF - Manufacturer
GlaxoSmithKline (abacavir, Trizivir).
LG - Language
French.
AT - Article type
Adverse-Reaction-Report.
AV - Availability
Abstract link:
<http://www.e2med.com/index.cfm?fuseaction=viewArt
Dossier& DArtIdx=160776& DIssIdx=9143& Dchap
Idx=68635&Amp; & Random=19505& fid=893549& cftoken
=27977296>.
YR - Publication year
2003.
DT - Publication date
20031000.
ED - Entry date
20031104.
Label/Description Example
AN Accession number 1_: 0000160625.AN.
& update date - see Limit options -
TI Title 2_: PHARMACOKINETICS WITH
DAPTOMYCIN.TI.
TT Title in original language 3_: ABACAVIR WITH
HEPATITE.TT.
SO Source 4_: PRESSE-MEDICALE.SO.
or 5_: PRESSE ADJ
MEDICALE.SO.
SO= Source journal name
- to retrieve a full list of
source journals in LINE 6_: ..ROOT SO=
VOLUME= Volume number 7_: VOLUME=47
ISSUE= Issue number 8_: ISSUE=4
PAGE= Page number 9_: PAGE=1557$
ISSN= ISSN 10_: ISSN= 0066-4804
AU Author(s) 11_: DEBRUIN-M-F.AU.
or 12_: FERRY.AU.
- to retrieve a list of authors
with the same surname 13_: ..ROOT BLAIR.AU.
AB Abstract 14_: SYPHILITIC ADJ
HEPATITIS
- to retrieve only documents
with abstracts 15_: ABSTRACT=YES
DE Descriptors 16_: VOLUNTEERS-HUMAN.DE.
or 17_: HALF ADJ LIFE.DE.
MF Manufacturer 18_: GLAXO$ WITH
TRIZIVIR.MF.
LG Language 19_: FRENCH.LG.
- to retrieve a full list of
languages covered in LINE 20_: ..ROOT LG=
AT Article type 21_: ADVERSE ADJ REACTION
ADJ REPORT.AT.
or 22_: ADVERSE-REACTION-
REPORT.AT.
- to retrieve a full list of
article types covered in LINE 23_: ..ROOT AT=
AV Availability 24_: ABSTRACT ADJ LINK.AV.
YR Publication year 25_: 2004.YR.
YEAR= Publication year 26_: YEAR=2005
- see also Limit options -
DT Publication date 27_: 20040726.DT
DATE= Publication date 28_: DATE=20030430
MONTH= Publication month 29_: MONTH=200304
- see also Limit options -
ED Entry date 30_: 20040610.ED.
- see also Limit options -
1_: DRUG ADJ THERAPY.AB.
DATE Publication date 2_: ..L 1 DATE > 20041231
MONTH Publication month 3_: ..L 1 MONTH WL
200403,200405
YEAR Publication year 4_: ..L 1 YEAR EQ 2005
ED Entry date 5_: ..L 1 ED < 20050731
UDATE Update date 6_: ..L 1 UDATE =
20000818
UMONTH Update month 7_: ..L 1 UMONTH=200501.
y paragraph - title, author _: ..P TI, AU 1-5
HORT AN TI TT SO AU YR
EDIUM AN TI TT SO AU AB LG YR
ONG AN TI TT SO AU AB DE MF LG YR
LL AN TI TT SO AU AB DE MF LG AT AV YR DT ED
REE AN TI TT DE MF LG AT YR DT ED
_: ..P LONG 6-15.
TT - Titles in original language:
A small number of documents have only an original (non-English
language) title. Rather than indicating in TI that the document is
'Untitled' (ie. it has no English-language title, this is repeated
in the TI paragraph
Search options:
..SET PLURALS ON and ..SET MEDWORD ON may be selected in CABI.
Guides:
The full guide to Pharm-line is available online in the BASE
database - search as BASE-LINE.
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