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The full text of this eminent medical journal.
NEJM has the highest 'Impact Factor' of any general medical journal
in the world. The New England Journal of Medicine
publishes original research reports, reviews and commentary on all
aspects of biomedical science, clinical practice and health policy.
The NEJM is owned and published by the Massachusetts Medical
Society. Before inclusion, articles are subject to thorough peer
review, to maintain the NEJMs world class reputation.
The articles consist of original research submitted from around the
world. The NEJM also contains case records, editorials, a letters
section and book reviews. NEJM will be of interest to clinicians
and anyone involved in medical research.
The databases emphasis is on internal medicine and speciality areas,
including: allergy/immunology, cardiology; endocrinology,
gastroenterology, hematology, nephrology, neurology, oncology,
pulmonary disease, rheumatology, HIV and infectious diseases.
NEJM includes major, previously unpublished clinical research
reports; overviews of important clinical topics; healthcare policy
and reform; medical ethics; medical education; applications of
clinical research; diagnostics; international medical topics; legal
implications.
Use NEJM to answer questions like:
- what are the latest research findings on zidovudine?
- what are the signs of melanoma?
- are there any recent review articles on diabetes mellitus?
- have any books on surgery been reviewed lately?
- what is the best treatment for otitis media in children?
Sources:
NEJM is the online equivalent of The New England Journal of
Medicine, excluding advertisements, tables and figures.
Accession number & update
MJBA-320301. 950914.
Title
Asthma and Wheezing in the First Six Years of Life.
Author(s)
Martinez-Fernando-D; Wright-Anne-L; Taussig-Lynn-M; Holberg-
Catharine-J; Halonen-Marilyn; Morgan-Wayne-J; the-Group-Health-
Medical-Associates.
Author affiliation
From the Respiratory Sciences Center (F.D.M., A.L.W., L.M.T.,
C.J.H., M.H., W.J.M.) and the Department of Pediatrics (F.D.M.,
A.L.W., L.M.T., W.J.M.), University of Arizona College of
Medicine, Tucson. Address reprint requests to Dr. Martinez at the
Respiratory Sciences Center, Arizona Health Sciences Center, 1501
N. Campbell Ave., Tucson, AZ 85724.
Supported by a Specialized Center of Research Grant (HL14136)
from the National Institutes of Health.
The members of the Group Health Medical Associates were John
Bean, M.D., Henry Bianchi, M.D., John Curtiss, M.D., John Ey,
M.D., Alejandro Sanguineti, M.D., Barbara Smith, M.D., Terry
Vondrak, M.D., Neil West, M.D., and Maureen McLellan, R.N.,
P.N.P.
Source
The New England Journal of Medicine; 1995 Jan 19; Vol 332 (3); pp
133-138. ISSN: 0028-4793.
Publication date
950119.
Abstract
Abstract
Background: Many young children wheeze during viral respiratory
infections, but the pathogenesis of these episodes and their
relation to the development of asthma later in life are not well
understood.
Methods: In a prospective study, we investigated the factors
affecting wheezing before the age of three years and their
relation to wheezing at six years of age. Of 1246 newborns in the
Tucson, Arizona, area enrolled between May 1980 and October 1984,
follow-up data at both three and six years of age were available
(...)
Results: At the age of six years, 425 children (51.5 percent) had
never wheezed, 164 (19.9 percent) had had at least one lower
respiratory tract illness with wheezing during the first three
years of life but had no wheezing at six years of age, 124 (15.0
percent) had no wheezing before the age of three years but had
(...)
Conclusions: The majority of infants with wheezing have transient
conditions associated with diminished airway function at birth
and do not have increased risks of asthma or allergies later in
life. In a substantial minority of infants, however, wheezing
episodes are probably related to a predisposition to asthma. (N
Engl J Med 1995; 332:133-8.).
Text
Although asthma may originate soon after birth, *CR 1* the
natural history of the disease is poorly understood. Many infants
have episodes of wheezing associated with viral respiratory
illnesses. *CR 2* Neither the pathogenesis of these episodes nor
their relation to asthma has been completely elucidated. *CR 3*
(...)
Methods
The children we studied were enrolled as newborns between May
1980 and October 1984 in the Tucson Children's Respiratory Study.
*CR 9* Their parents were patients of Group Health Medical
Associates, a large health maintenance organization in Tucson,
Arizona, and were contacted shortly after their children were
born. Informed consent was obtained from the parents of 1246
newborns.
(...)
Results
When the 826 children included in this study were compared with
the 420 who were excluded because of incomplete data, the
frequency of a family history of asthma and the distribution of
ethnic backgrounds were similar. However, the children with
complete data tended to belong to families with a higher
(...)
We are indebted to Benjamin Burrows, M.D., for his advice; to
Marilyn Smith, R.N., and Lydia De La Ossa, R.N., the study
nurses; to Shelley Radford and Bruce Saul for technical
assistance; and to Maureen Cameron for assistance in the
preparation of the manuscript.
Copyright 1995 by the Massachusetts Medical Society.
Cited references
1. Martinez FD.
The origins of asthma in early life.
In: Postma DS, Gerritsen J, eds.
Proceedings of the Bronchitis V International Symposium,
Groningen, the Netherlands.
Assen, the Netherlands: Van Gorcum, 1994:161-9.
(...)
24. Redline S, Tager IB, Segal MR, Gold D, Speizer FE, Weiss ST.
The relationship between longitudinal change in pulmonary
function and nonspecific airway responsiveness in children and
young adults.
Am Rev Respir Dis 1989; 140:179-84.
Article type
Original Articles.
Occurrences
Accession number & update (1)
Length
35,249 Characters, approximately 21 PC screens.
Label/description Example
AN Accession number 1_: 320301.AN.
& update - see Limit options -
TI Title 2_: ASTHMA SAME WHEEZING.TI.
AU Author(s) 3_: WRIGHT-A$.AU.
IN Author affiliation 4_: RESPIRATORY ADJ
SCIENCES.IN.
SO Source 5_: NEW ADJ ENGLAND
DT Publication date
DATE= Publication date 6_. DATE=19980706
MONTH= Publication month 7_: MONTH=199807
YEAR= Publication year 8_: YEAR=1998
AB Abstract 9_: PULMONARY ADJ FUNCTION.AB.
TX Text 10_: SERUM WITH LEVEL.TX.
CR Cited references 11_: TUCSON WITH STUDY.CR.
AT Article type 12_: ORIGINAL ADJ ARTICLE.AT.
OC Occurrences - Display only -
LE Length - Display only -.
VOL Volume number 1_: VOL=332
PG Page number 2_: PG=133
1_: ASTHMA
DATE Publication date YYYYMMDD 2_: ..L 1 DATE>19980726
MONTH Publication month YYYYMM 3_: ..L 1 MONTH EQ 199807
YEAR Publication year YYYY 4_: ..L 1 YEAR WL 1998,1999
UDATE Update date YYYYMMDD 5_: ..L 1 UDATE GT 19990622
UMONTH Update month YYYYMM 6_: ..L 1 UMONTH<199906.
By paragraph - title, author _: ..P TI, AU 1-5
SHORT AN TI AU SO OC LE
MEDIUM AN TI AU IN SO AB TX OC LE
LONG AN TI AU IN SO AB TX CR OC LE
ALL AN TI AU IN SO DT AB TX CR AT OC LE
KWIC Context of search terms in AB, TX paragraphs
HITS All paragraphs where search terms occur
FREE AN TI DT AT OC LE.
Searching text:
Articles can be lengthy, so avoid using AND to link search terms -
use ADJ, WITH (same sentence) or SAME (same paragraph), eg:
1_: EVENING ADJ PRIMROSE ADJ OIL WITH NEUROPATHY
Search options:
..SET PLURALS ON and ..SET MEDWORD ON can be selected in NEJM.
Guides:
The guide to NEJM is published in the DataStar Biomedical Manual,
Berne, and online in BASE (search BASE-NEJM).
.
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