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RTECS provides data on the acute and chronic toxic effects of
chemical substances.
The RTEC database covers over 100,000 chemicals both naturally
occurring and man-made, including food additives, dyes, detergents,
prescription and non-prescription drugs, fungicides, herbicides,
pesticides, solvents, diluents, chemical wastes and other industrial
chemicals. Chemical substances can be identified using CAS registry
number, any known chemical name, molecular formulae as well as toxic
effects. Information on muatgenicity, carcinogenicity, skin and eye
irritation, reproductive studies, and other toxic effect tests can
be located in RTEC.
In each document, paragraphs T1 to T5 contain the toxic effects
data. Every study included will give details on species, route,
dose and other important information. Selected US Federal Standards
and Regulations and NIOSH (National Institute for Occupational
Safety & Health) recommended exposure levels can be found in text
paragraphs T6 and T7. Toxicology and carcinogenicity reviews are
also cited in paragraph T7.
All those with working with chemicals in research, industry and
government bodies will find a use for RTEC as will those involved
with health and safety aspects of the chemical and waste products
industry.
Use RTEC to answer questions like:
- what, if any, are the carcinogenic effects of sweet gum?
- what are all the known toxic effects of aniline?
- have any eye-irritation studies been written for Sorbyl alcohol?
- what mutagenicity studies have been written for potassium
chloride?
Sources:
RTEC is derived from published scientific literature, articles,
monographs, and from published and unpublished Government reports.
Accession number & update
NIOSH-KJ3150000 19940505.
Occurrences
PARAGRAPH
AN (1)
Chemical name
ETHANE, 1,1,2-TRICHLORO-.
Synonyms
Synonyms:
ETHANE TRICHLORIDE; NCI-C04579; RCRA WASTE NUMBER U227; RCRA
WASTE NUMBER U359; beta-T; beta-TRICHLOROETHANE; 1,1,2-
TRICHLORETHANE; 1,1,2-TRICHLOROETHANE; 1,2,2-TRICHLOROETHANE;
1,1,2-TRICHLOROETHANE (ACGIH, OSHA); TROJCHLOROETAN(1,1,2)
(Polish); VINYL TRICHLORIDE.
Document revision month
LAST REVISION DATE: 199404.
CAS registry numbers
79-00-5.
Molecular formula
Formula: C2-H3-Cl3
Weight : 133.40
Wiswesser Line Notation: GYG1G.
Classification codes
A Agricultural-Chemical; C Tumorigen; D Drug; M Mutagen; S
Primary-Irritant.
Length
8,255 Characters, approximately 5 PC screens.
Table of contents
Mutagenicity Studies (MSTU) T1
Carcinogenicity Studies (CSTU) T2
Skin and Eye Irritation Studies (SSTU) T3
General Toxicity Studies (GSTU) T4
Multiple Dose Studies (MDSTU) T4
Toxicology and Carcinogenicity Review (TOXR) T6
Exposure Standards and Regulations (EXSR) T7.
Mutagenicity studies
- Mutagenicity Studies - MSTU -
Test System : mmo.
Species/Route/Cell Type : sat.
Dose : 10 ug/plate.
Reference : TECSDY 15,101,87 Toxicological
and Environmental Chemistry.
(Gordon & Breach Science Pub.
Inc., 1 Park Ave., New York, NY
10016) V.3(3/4)- 1981-.
- Mutagenicity Studies - MSTU -
Test System : mma.
Species/Route/Cell Type : sat.
Dose : 10 ug/plate.
Reference : TECSDY 15,101,87 Toxicological
and Environmental Chemistry.
(Gordon & Breach Science Pub.
Inc., 1 Park Ave., New York, NY
10016) V.3(3/4)- 1981-.
- Mutagenicity Studies - MSTU -
Test System : oms.
Species/Route/Cell Type : esc.
Dose : 135 mmol/L.
Reference : EMMUEG 19,98,92 Environmental
and Molecular Mutagenesis.
(Alan R. Liss, Inc., 41 E. 11th
St., New York, NY 10003) V.10-
1987-.
- Mutagenicity Studies - MSTU -
Test System : sln.
Species/Route/Cell Type : asn.
Dose : 750 ppm.
Reference : MUREAV 201,401,88 Mutation
Research. (Elsevier Science
Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1-
1964-.
- Mutagenicity Studies - MSTU -
Test System : otr.
Species/Route/Cell Type : mus:emb.
Dose : 25 mg/L.
Reference : CALEDQ 28,85,85 Cancer Letters
(Shannon, Ireland). (Elsevier
Scientific Pub. Ireland Ltd.,
POB 85, Limerick, Ireland) V.1-
1975-.
- Mutagenicity Studies - MSTU -
Test System : cyt.
Species/Route/Cell Type : gpg-skn.
Dose : 2880 ug/kg.
Reference : APTOA6 41,298,77 Acta
Pharmacologica et Toxicologica.
(Copenhagen, Denmark) V.1-59,
1945-86. For publisher
information, see APTSAI..
- Mutagenicity Studies - MSTU -
Test System : dnd.
Species/Route/Cell Type : mam:lym.
Dose : 1 mmol/L.
Reference : TOLED5 11,243,82 Toxicology
Letters. (Elsevier Science Pub.
B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1-
1977-.
Carcinogenicity studies
- Carcinogenicity Studies - CSTU -
Route : orl.
Species : mus.
Study Type : TDLo.
Dose : 76 gm/kg/78W-I.
Effect A : V01.
Effect B : L60.
Effect C : N61.
Reference : NCITR* NCI-TR-74,78 National
Cancer Institute Carcinogenesis
Technical Report Series.
(Bethesda, MD) No.0-205. For
publisher information, see
NTPTR*..
- Carcinogenicity Studies - CSTU -
Route : orl.
Species : mus.
Study Type : TD.
Dose : 152 gm/kg/78W-I.
Effect A : V01.
Effect B : L60.
Effect C : N61.
Reference : NCITR* NCI-TR-74,78 National
Cancer Institute Carcinogenesis
Technical Report Series.
(Bethesda, MD) No.0-205. For
publisher information, see
NTPTR*..
Skin & eye irritation
- Skin and Eye Irritation Studies - SSTU -
Route : skn.
Species : rbt.
Effect : 500 mg open MLD.
Reference : UCDS** 6/28/72 Union Carbide
Data Sheet. (Union Carbide
Corp., 39 Old Ridgebury Rd.,
Danbury, CT 06817).
- Skin and Eye Irritation Studies - SSTU -
Route : skn.
Species : rbt.
Effect : 810 mg/24H SEV.
Reference : EJTXAZ 9,171,76 European
Journal of Toxicology and
Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For
publisher information, see
TOERD9..
- Skin and Eye Irritation Studies - SSTU -
Route : skn.
Species : rbt.
Effect : 500 mg/24H MLD.
Reference : 85JCAE -,95,86 "Prehled
Prumyslove Toxikologie;
Organicke Latky, " Marhold, J.,
Prague, Czechoslovakia,
Avicenum, 1986.
- Skin and Eye Irritation Studies - SSTU -
Route : eye.
Species : rbt.
Effect : 162 mg MLD.
Reference : EJTXAZ 9,171,76 European
Journal of Toxicology and
Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For
publisher information, see
TOERD9..
- Skin and Eye Irritation Studies - SSTU -
Route : eye.
Species : rbt.
Effect : 500 mg/24H MLD.
Reference : 85JCAE -,95,86 "Prehled
Prumyslove Toxikologie;
Organicke Latky, " Marhold, J.,
Prague, Czechoslovakia,
Avicenum, 1986.
- Skin and Eye Irritation Studies - SSTU -
Route : skn.
Species : gpg.
Effect : 1440 mg/15M.
Reference : APTOA6 41,298,77 Acta
Pharmacologica et Toxicologica.
(Copenhagen, Denmark) V.1-59,
1945-86. For publisher
information, see APTSAI..
General toxicity studies
- General Toxicity Studies - GSTU -
Route : orl.
Species : rat.
Study Type : LD50.
Dose : 836 mg/kg.
Reference : TSCAT* OTS0515584 Office of
Toxic Substances Report. (U.S.
Environmental Protection
Agency, Office of Toxic
Substances, 401 M St., SW,
Washington, DC 20460).
- General Toxicity Studies - GSTU -
Route : ihl.
Species : rat.
Study Type : LCLo.
Dose : 2000 ppm/4H.
Reference : JIHTAB 31,343,49 Journal of
Industrial Hygiene and
Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher
information, see AEHLAU..
- General Toxicity Studies - GSTU -
Route : ipr.
Species : rat.
Study Type : LD50.
Dose : 265 mg/kg.
Reference : ENVRAL 40,411,86 Environmental
Research. (Academic Press,
Inc., 1 E. First St., Duluth,
MN 55802) V.1- 1967-.
- General Toxicity Studies - GSTU -
Route : orl.
Species : mus.
Study Type : LD50.
Dose : 378 mg/kg.
Effect A : F07.
Effect B : J30.
Effect C : K06.
Reference : DCTODJ 8,333,85 Drug and
Chemical Toxicology. (Marcel
Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78-.
- General Toxicity Studies - GSTU -
Route : ipr.
Species : mus.
Study Type : LD50.
Dose : 494 mg/kg.
Reference : TXAPA9 9,139,66 Toxicology and
Applied Pharmacology. (Academic
Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959-.
- General Toxicity Studies - GSTU -
Route : scu.
Species : mus.
Study Type : LD50.
Dose : 227 mg/kg.
Reference : JPETAB 123,224,58 Journal of
Pharmacology and Experimental
Therapeutics. (Williams &
Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.1-
1909/10-.
- General Toxicity Studies - GSTU -
Route : orl.
Species : dog.
Study Type : LDLo.
Dose : 500 mg/kg.
Effect A : F04.
Effect B : L02.
Reference : AJHYA2 16,325,32 American
Journal of Hygiene. (Baltimore,
MD) V.1-80, 1921-64. For
publisher information, see
AJEPAS..
- General Toxicity Studies - GSTU -
Route : ipr.
Species : dog.
Study Type : LD50.
Dose : 450 mg/kg.
Effect A : L14.
Reference : TXAPA9 10,119,67 Toxicology and
Applied Pharmacology. (Academic
Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959-.
- General Toxicity Studies - GSTU -
Route : ivn.
Species : dog.
Study Type : LDLo.
Dose : 95 mg/kg.
Reference : QJPPAL 7,205,34 Quarterly
Journal of Pharmacy &
Pharmacology. (London, UK)
V.2-21, 1929-48. For publisher
information, see JPPMAB..
- General Toxicity Studies - GSTU -
Route : ihl.
Species : cat.
Study Type : LCLo.
Dose : 13100 mg/m3/4.5H.
Effect A : D35.
Effect B : F01.
Effect C : K01.
Reference : AHBAAM 116,131,36 Archiv fuer
Hygiene und Bakteriologie.
(Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For
publisher information, see
ZHPMAT..
- General Toxicity Studies - GSTU -
Route : skn.
Species : rbt.
Study Type : LD50.
Dose : 5377 mg/kg.
Reference : AIHAAP 30,470,69 American
Industrial Hygiene Association
Journal. (AIHA, 475 Wolf Ledges
Pkwy., Akron, OH 44311) V.19-
1958-.
- General Toxicity Studies - GSTU -
Route : scu.
Species : rbt.
Study Type : LDLo.
Dose : 500 mg/kg.
Reference : QJPPAL 7,205,34 Quarterly
Journal of Pharmacy &
Pharmacology. (London, UK)
V.2-21, 1929-48. For publisher
information, see JPPMAB..
- General Toxicity Studies - GSTU -
Route : skn.
Species : gpg.
Study Type : LDLo.
Dose : 970 mg/kg.
Reference : AOHYA3 19,115,76 Annals of
Occupational Hygiene. (Pergamon
Press Inc., Maxwell House,
Fairview Park, Elmsford, NY
10523) V.1- 1958-.
- General Toxicity Studies - GSTU -
Route : ipr.
Species : gpg.
Study Type : LDLo.
Dose : 970 mg/kg.
Reference : AOHYA3 19,115,76 Annals of
Occupational Hygiene. (Pergamon
Press Inc., Maxwell House,
Fairview Park, Elmsford, NY
10523) V.1- 1958-.
- Multiple Dose Studies - MDSTU -
Route : orl.
Species : mus.
Study Type : TDLo.
Dose : 532 mg/kg/14D-I.
Effect A : A70.
Effect B : N74.
Effect C : Z73.
Reference : DCTODJ 8,333,85 Drug and
Chemical Toxicology. (Marcel
Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78-.
- Multiple Dose Studies - MDSTU -
Route : orl.
Species : mus.
Study Type : TDLo.
Dose : 27 gm/kg/90D-C.
Effect A : L30.
Effect B : U01.
Effect C : Y03.
Reference : DCTODJ 8,333,85 Drug and
Chemical Toxicology. (Marcel
Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78-.
Tox & carcinogen review
- Threshold Limit Value - TLV -
ACGIH TLV-TWA 10 ppm (skin) 85INA8 6,1607,91.
- Cancer Review - CREV -
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMEMDT 20,533,79.
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMEMDT 52,337,91.
IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT 20,533,79.
IARC CANCER REVIEW:HUMAN NO AVAILABLE DATA IMEMDT 52,337,91.
IARC CANCER REVIEW:GROUP 3 IMSUDL 7,56,87.
IARC CANCER REVIEW:GROUP 3 IMEMDT 52,337,91.
- Toxicology Review - TREV -
TOXICOLOGY REVIEW FAZMAE 18,365,74.
TOXICOLOGY REVIEW AIHAAP 40(3), A46,79.
- NIOSH Recommended Limits - NREC -
NIOSH REL TO 1,1,2-TRICHLOROETHANE-air:10H CA TWA 10 ppm (Sk)
NIOSH* DHHS #92-100,92.
- NIOSH Exposure Surveys - NEXP -
NOHS 1974: HZD 73770; NIS 12; TNF 1422; NOS 18; TNE 10453.
NOES 1983: HZD 73770; NIS 4; TNF 95; NOS 12; TNE 1038; TFE 16.
Exposure standards & regs
- Standards and Regulations - SREG -
MSHA STANDARD-air:TWA 10 ppm (45 mg/m3) (skin) DTLVS* 3,263,71.
OSHA PEL:8H TWA 10 ppm (45 mg/m3)(skin) FEREAC 54,2923,89.
OSHA PEL FINAL:8H TWA 10 ppm (45 mg/m3)(skin) FEREAC 54,2923,89.
OEL-ARAB Republic of Egypt:TWA 10 ppm (40 mg/m3); Skin JAN93.
OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3); Skin JAN93.
OEL-BELGIUM:TWA 10 ppm (55 mg/m3); Skin JAN93.
OEL-DENMARK:TWA 10 ppm (54 mg/m3); Skin JAN93.
OEL-FINLAND:TWA 10 ppm (54 mg/m3); STEL 20 ppm (110 mg/m3); Skin
JAN93.
OEL-GERMANY:TWA 10 ppm (55 mg/m3); Skin; Carcinogen JAN93.
OEL-HUNGARY:TWA 10 mg/m3; STEL 20 mg/m3; Skin JAN93.
OEL-JAPAN:TWA 10 ppm (55 mg/m3); Skin JAN93.
OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3); Skin JAN93.
OEL-POLAND:TWA 100 mg/m3 JAN93.
OEL-RUSSIA:TWA 10 ppm JAN93.
OEL-SWITZERLAND:TWA 10 ppm (55 mg/m3); STEL 50 ppm; Skin JAN93.
OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3); STEL 20 ppm; Skin
JAN93.
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV.
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV.
- Federal Program Status - STAT -
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/196411/AS).
EPA TSCA CHEMICAL INVENTORY, JUNE 1993.
EPA TSCA SECTION 8(e) STATUS REPORT 8EHQ-0979-0310.
On EPA IRIS database.
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 1994.
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978.
NIOSH ANALYTICAL METHODS: see HYDROCARBONS, HALOGENATED, 1003.
NCI CARCINOGENESIS BIOASSAY (GAVAGE); CLEAR EVIDENCE:MOUSE NCITR*
NCI-TR-74,78.
NCI CARCINOGENESIS BIOASSAY (GAVAGE); NO EVIDENCE:RAT NCITR* NCI-
TR-74,78.
OSHA ANALYTICAL METHOD #11.
Label/Description Example
AN Accession number 1_: KJ3150000
& update 2_: 19950810.AN.
OC Occurrences - display only
TI Chemical name 3_: ETHANE WITH TRICHLORO.TI.
NM Title (Chemical name) 4_: ANILINE.NM..W.
SY Synonyms 5_: VINYL ADJ TRICHLORIDE.SY.
6_: VINYL-TRICHLORIDE
DT Document revision month 7_: 199404.DT.
RN CAS registry numbers 8_: 79-00-5
MF Molecular formula 9_: C2-H3-C13.MF.
CC Classification codes 10_: MUTAGEN.CC.
NT Notes 11_: ALKALOIDS.NT.
LE Length - Display only
TC Table of contents - Display only
T1 Mutagenicity studies 12_: MMO.T1.
T2 Carcinogenicity studies 13_: ORL SAME TDL$1.T2.
T3 Skin & eye irritation studies 14_: SKIN SAME
(DATA ADJ SHEET).T3.
T4 General toxicity studies 15_: RAT SAME LD50.T4.
T5 Reproductive studies 16_: CHEMICAL ADJ TOXICOLOGY.T5.
T6 Tox & carcinogenicity review
17_: NIOSH SAME PROPYL.T6.
T7 Exposure standards &
regs 18_: OEL WITH SWITZERLAND.T7.
CC Classification codes 1_: CC=A
SC Section headings 2_: SC=MSTU
EFFECT (In T- paragraphs) 3_: EFFECT=A01
In DT paragraph:
YM= Revision month 4_: YM=199307
YR= Revision year 5_: YR=1994
1_: ALKALOIDS
MW Molecular weight 2_: ..L MW>250
YM Document revision month 3_: ..L 1 YM=198903
UDATE Update date YYYYMMDD 4_: ..L 1 UDATE GT 19940726
UMONTH Update month YYYYMM 5_: ..L 1 UMONTH>199507.
By paragraph - title, table of contents _: ..P TI, TC 1
SHORT AN OC TI/NM SY RN MF NT LE TC
MEDIUM AN OC TI/NM SY RN MF CC NT LE TC
LONG AN OC TI/NM SY DT RN MF CC NT LE TC HITS
ALL AN OC TI/NM SY DT MF CC LE TC T1 T2 T3 T4 T5 T6 T7
HITS All paragraphs where search terms occur *
FREE AN OC TI/NM LE TC
_: ..P 1 MEDIUM 5
* HITS prints the sections from T numbered paragraphs containing
search terms (not the whole T paragraph).
Search options:
..SET PLURALS ON and ..SET MEDWORD ON can be selected in RTEC..
Alerts: Are not available on RTEC
..RANK and ..MAP are available on TI/NM SY RN paragraphs
Guides:
The guide to RTEC is published in the DataStar Biomedical and
Chemical Manuals, Berne, and online in BASE - search BASE-RTEC.
MDL Information Inc.
RTECSŪ is a United States trademark owned and licensed under
authority of the U.S. Government, by and through MDL Information
Systems, Inc.
The RTECS database and derivative works are provided "as is" without
warranty of any kind; neither party, nor PHS, makes any warranties
to the other party or any other person or entity with respect to the
rtecs database or derivative works or any licenses and hereby
expressly disclaims all implied warranties, including, without
limitation, warranties of merchantability, fitness for a particular
purpose and non infringement. Further, neither party nor phs
warrants that the RTECS database or derivative works will meet the
other party's requirements, or that operation of the rtecs database
or derivative works will be uninterrupted or error-free, the rtecs
database will operate properly as integrated in licensee's
product(s) or in any end user's environment or that defects in the
rtecs database or derivative works will be corrected.
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